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Neurosci Lett. 1994 Feb 14;167(1-2):175-8.

Potentiation of N-methyl-D-aspartate receptor-dependent afterdischarges in rat dentate gyrus following in vitro ethanol withdrawal.

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  • 1Department of Pharmacology, University of Nebraska Medical Center, Omaha 68198-6260.


The contribution of NMDA receptors to neuronal hyperexcitability following in vitro ethanol withdrawal was examined using afterdischarges (ADs) in rat dentate gyrus as a model system. ADs were evoked by high frequency stimuli and blocked by N-methyl-D-aspartate (NMDA) receptor antagonists. Ethanol (75 mM) inhibited ADs, and following in vitro ethanol withdrawal, the duration of afterdischarges was significantly enhanced (37 +/- 2%, n = 21). Therefore, in vitro ethanol exposure with subsequent withdrawal is associated with an enhancement of NMDA receptor-dependent afterdischarges. These results are consistent with the involvement of NMDA receptors in ethanol withdrawal hyperexcitability.

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