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Exp Cell Res. 1994 May;212(1):151-4.

Enhancement of CDP-DG:inositol transferase activity in src- and erbB2-transformed cells.

Author information

1
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.

Abstract

Phosphatidylinositol (PI) synthesis was activated in Rous sarcoma virus-infected NIH3T3 or activated erbB2-transformed NIH3T3 cells. The in vitro activity of CDP-DG:inositol transferase prepared from these cells was also higher than that from normal parent NIH3T3 cells, although phospholipase C and PI kinase activities were not significantly different among these cells. A tyrosine kinase inhibitor, erbstatin, inhibited the PI synthesis in cultured cells, suggesting that Src and ErbB2-associated tyrosine kinases are involved in activation of CDP-DG:inositol transferase in these cell lines.

PMID:
7909754
DOI:
10.1006/excr.1994.1129
[Indexed for MEDLINE]

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