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Lancet. 1994 Apr 16;343(8903):950-1.

Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation.

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  • 1St Vincent Medical Center, Los Angeles, CA 90057.

Abstract

Identification of a biocompatible immunoprotective membrane to prevent graft rejection remained elusive until the development of microcapsules formulated in alginate high in guluronic acid. We report insulin independence in a type 1 diabetic patient after encapsulated islet transplantation. Encapsulated human islets were injected intraperitoneally in a diabetic patient with a functioning kidney graft. Insulin independence with tight glycaemic control was demonstrated 9 months after the procedure. These results warrant a trial of a high dose of encapsulated islets in early-onset diabetic patients.

PMID:
7909011
[PubMed - indexed for MEDLINE]
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