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Lancet. 1994 Feb 12;343(8894):388-90.

Hepatitis C virus in multiple episodes of acute hepatitis in polytransfused thalassaemic children.

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Institute of Internal Medicine, University of Cagliari, Italy.


We investigated the course of distinct episodes of acute non-A, non-B (NANB) hepatitis in three polytransfused thalassaemic children. In each case, the first episode was associated with the appearance of serum hepatitis C virus (HCV) RNA and anti-HCV seroconversion. The second episode was accompanied by the reappearance of HCV viraemia, which in two patients was due to reinfection with a different HCV strain and in the third could be the result of either reactivation of primary infection or reinfection with a new but closely related strain. Thus HCV infection may not induce protective immunity, which has implications for vaccine development.

[Indexed for MEDLINE]

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