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Immunol Today. 1993 Nov;14(11):547-53.

Control points in early T-cell development.

Author information

1
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304.

Abstract

Intrathymic T-cell differentiation involves the generation, expansion and selection of distinct T-lymphocyte subsets. While positive and negative selection have been a focal point of T-cell development, these events represent the final stages in a complicated sequence of differentiation steps. Here, Dale Godfrey and Albert Zlotnik summarize recent advances in our understanding of early T-cell development and describe five 'control points' that identify key events in this sequence.

PMID:
7903854
DOI:
10.1016/0167-5699(93)90186-O
[Indexed for MEDLINE]

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