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Trends Biochem Sci. 1993 Sep;18(9):324-7.

Tetanus and botulism neurotoxins: a new group of zinc proteases.

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Department of Biomedical Sciences, University of Padova, Italy.


The active forms of tetanus and botulinum neurotoxins, released from the precursor molecule by specific proteolysis and reduction, block the release of neurotransmitters via a Zn(2+)-dependent protease activity. VAMP/synaptobrevin, an integral membrane protein of the synaptic vesicles, is cleaved at a single site by tetanus and botulinum B, D and F neurotoxins. The unique sequence, mechanism of activation and site of activity of clostridial neurotoxins mark them out as an independent group of Zn(2+)-endopeptidases.

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