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Brain Res Mol Brain Res. 1993 Sep;19(4):353-5.

BCL-2 blocks glutamate toxicity in neural cell lines.

Author information

1
Department of Neurology, UCLA School of Medicine 90024-1769.

Abstract

Glutamate has been shown, at high concentrations (5-10 mM), to lead to death in cells of the pheochromocytoma cell line PC12. We report that similar concentrations of glutamate also kill immortalized central neural cell lines, and that the expression of the proto-oncogene bcl-2 in these cell lines blocks glutamate neurotoxicity. Potassium chloride (25 mM) also protects a cerebellar neuronal cell line, but not PC12 cells, from glutamate toxicity.

PMID:
7901730
DOI:
10.1016/0169-328x(93)90139-g
[Indexed for MEDLINE]

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