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Community Dent Oral Epidemiol. 1993 Oct;21(5):313-6.

Association of psychotropic drugs, prevalence of denture-related stomatitis and oral candidosis.

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Department of Prosthetic Dentistry, United Medical School, Guy's Hospital, London, United Kingdom.


The aims of this study were 1) to determine the association between the prevalence of denture-related stomatitis and oral candidosis in patients undergoing long-term treatment with psychotropic drugs and 2) to identify the relationships between an increased prevalence of oral candidosis, denture cleanliness, dietary habits and cigarette smoking in these patients. Clinical and laboratory investigation of psychiatric patients under treatment with psychotropic drugs and who were wearing complete maxillary dentures, compared with control (non-psychiatric) patients revealed that 1) the isolation frequency of candida was 64.7% compared with 33.3% in the controls; 2) palatal inflammation was present in 74.5% compared with 55% of the controls; 3) oral staphylococcus carriage was present in 56.9% compared with 17.6% of the controls; 4) cigarette smoking, sugar consumption and a poor standard of denture hygiene were more common in the psychiatric patients than in the controls.

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