Format

Send to

Choose Destination
Pathol Res Pract. 1994 Oct;190(9-10):920-2.

Interferon-gamma, an anti-fibrogenic cytokine which binds to heparan sulfate.

Author information

1
Unité de Physiopathologie Cellulaire et Moléculaire des Fibroses Tissulaires-CNRS URA 1459, Institut Pasteur de Lyon, France.

Abstract

Interferon-gamma is a T cell secreted cytokine. It has a great number of biological activities, among which is the down regulation of collagen molecules. IFN-gamma acts through cell surface receptors, but also binds to heparan sulfate proteoglycans. In vivo, it is postulated that the heparan sulfate/IFN-gamma interaction can modulate the activity and availability of the cytokine.

PMID:
7899141
DOI:
10.1016/S0344-0338(11)80996-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center