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Pol J Pharmacol. 1994 Sep-Oct;46(5):467-70.

Effects of lamotrigine on absence seizures in rats.

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NICI, Department of Psychology, University of Nijmegen, The Netherlands.


Lamotrigine, a novel antiepileptic drug thought to inhibit the excitatory neurotransmitter release and indicated for convulsive seizures, was tested for its efficacy in modulating non-convulsive seizures of the absence type of epilepsy. This was done in a rat model for absence epilepsy: the WAG/Rij strain of rats. In side-effect free doses, lamotrigine did not inhibit absence seizures in these animals. Only in a high dose a reduction of spike-wave activity was noticed, but in that dose side-effects such as abnormal locomotion, were also seen. These findings underline the differential pharmacological profile of convulsive and non-convulsive generalized epilepsy.

[Indexed for MEDLINE]

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