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Int J Clin Lab Res. 1994;24(4):187-92.

Small, dense low-density lipoprotein as a risk factor for coronary heart disease.

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Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195.


Data from case-control and cross-sectional studies uniformly demonstrate an association between small, dense low-density lipoprotein and risk of coronary heart disease. This relationship may be attributable to the association of small, dense low-density lipoprotein with other atherogenic lipoproteins, the presence of the insulin resistance syndrome in subjects with small low-density lipoprotein, and/or the increased oxidative susceptibility of small, dense low-density lipoprotein particles. Furthermore, because small low-density lipoprotein appears to be a common trait in the general population, more than one of these atherogenic mechanisms may be operating simultaneously to increase risk of coronary heart disease.

[Indexed for MEDLINE]

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