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Radiology. 1995 Apr;195(1):35-40.

Intracranial aneurysms: MR angiographic screening in 400 asymptomatic individuals with increased familial risk.

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1
Department of Neurosurgery, University Hospital of Kuopio, Finland.

Abstract

PURPOSE:

To evaluate the accuracy and limitations of magnetic resonance (MR) angiographic screening for incidental intracranial aneurysms (IAs) in healthy individuals with a family history of IA.

MATERIALS AND METHODS:

Four hundred asymptomatic individuals in 68 families with a history of aneurysmal subarachnoid hemorrhage underwent MR angiography. Six families also had a history of polycystic kidney disease. A multislab, three-dimensional, time-of-flight sequence was used. Conventional angiography was performed to confirm positive MR angiographic findings.

RESULTS:

IAs were detected with MR angiography in 37 individuals, 32 of whom underwent conventional angiography. Intraobserver consistency was excellent (kappa = 0.96), and interobserver reproducibility was good to excellent (kappa = 0.59-0.82). Both techniques showed similar results in the evaluation of size, localization, and orientation of aneurysms and visibility of the aneurysm neck.

CONCLUSION:

MR angiography is an accurate and feasible method of noninvasive screening for IAs in individuals at high risk. Conventional angiography is still necessary before operative treatment.

[Indexed for MEDLINE]

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