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Ophthalmology. 1995 Mar;102(3):426-30.

Eyelid involvement in multicentric reticulohistiocytosis.

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1
Department of Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107.

Abstract

CASE REPORT:

The authors report the first biopsy-confirmed ocular adnexal involvement by multicentric reticulohistiocytosis. The patient was a 28-year-old black woman with a 15-year history of well-documented multicentric reticulohistiocytosis who had multiple dermal nodules and severe mutilating arthritis that had produced a characteristic telescoping deformity of the digits. Eyelid nodules were excised to relieve pseudoptosis and for cosmesis.

MATERIALS:

The eyelid nodules were studied by routine light microscopy and a battery of immunohistochemical stains, including S-100 protein and several macrophage markers.

RESULTS:

Microscopy disclosed an infiltrate of histiocytes and giant cells with glassy eosinophilic cytoplasm and large round or oval vesicular nuclei with prominent nucleoli set in a densely fibrotic stroma consistent with multicentric reticulohistiocytosis. The histiocytes showed positive immunoreactivity for lysozyme, but were negative for alpha-1 antichymotrypsin, S-100 protein, and neuron-specific enolase.

CONCLUSION:

Multicentric reticulohistiocytosis should be included in the differential diagnosis of multiple eyelid nodules.

PMID:
7891980
[Indexed for MEDLINE]
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