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Gynecol Obstet Invest. 1995;39(1):34-8.

Tobacco smoking impairs the local immunosurveillance in the uterine cervix. An immunohistochemical study.

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1
Department of Obstetrics and Gynecology, KU Leuven, Belgium.

Abstract

Previous reports have supported an association between tobacco smoking and cervical neoplasia. Our observations show an association between smoking and a reduction of the numerical densities of Langerhans cells and of helper/inducer T lymphocytes in the squamous epithelia of the transformation zone of the uterine cervix. This suggests a local impairment of cell-mediated immunity by smoking. This immunosuppressive effect could support the concept that smoking is an independent risk factor for cervical neoplasia.

PMID:
7890250
[Indexed for MEDLINE]
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