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Fertil Steril. 1995 Apr;63(4):816-9.

Late intracytoplasmic sperm injection in unexpected failed fertilization in vitro: diagnostic or therapeutic?

Author information

1
London Gynaecology and Fertility Centre, United Kingdom.

Abstract

OBJECTIVE:

To evaluate fertilization potential of 24-hour-old unfertilized oocytes using intracytoplasmic sperm injection and the pregnancy potential of resultant embryos.

DESIGN:

Prospective observational study.

SETTING:

Private infertility clinic, London, United Kingdom.

PATIENTS:

Fifteen patients with a history of infertility who underwent treatment with IVF and showed failure of fertilization on the day after oocyte retrieval.

INTERVENTION:

Assisted fertilization with intracytoplasmic sperm injection was carried out at 24 hours after oocyte retrieval.

RESULTS:

A total of 121 metaphase II oocytes were subjected to intracytoplasmic sperm injection. Of these, 9 were damaged (7%), 2 were polyploidic (2%), and 58 showed normal fertilization (48%). Of the latter, 47 cleaved normally (81%). Forty embryos were transferred and three were cryopreserved. One patient conceived (7%) but in this case only one of three embryos transferred was from intracytoplasmic sperm injection.

CONCLUSION:

Late (24 hours) intracytoplasmic sperm injection can give good fertilization and cleavage rates but the potential of the generated embryos to achieve pregnancy seems to be low.

PMID:
7890068
DOI:
10.1016/s0015-0282(16)57487-1
[Indexed for MEDLINE]

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