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EMBO J. 1995 Mar 1;14(5):1015-23.

Crystal structure of casein kinase-1, a phosphate-directed protein kinase.

Author information

1
W.M. Keck Structural Biology Laboratory, Cold Spring Harbor, NY 11724.

Abstract

The structure of a truncated variant of casein kinase-1 from Schizosaccharomyces pombe, has been determined in complex with MgATP at 2.0 A resolution. The model resembles the 'closed', ATP-bound conformations of the cyclin-dependent kinase 2 and the cAMP-dependent protein kinase, with clear differences in the structure of surface loops that impart unique features to casein kinase-1. The structure is of unphosphorylated, active conformation of casein kinase-1 and the peptide-binding site is fully accessible to substrate.

PMID:
7889932
PMCID:
PMC398173
[Indexed for MEDLINE]
Free PMC Article

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