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Trends Microbiol. 1994 Dec;2(12):481-5.

Acyclovir-resistant, pathogenic herpesviruses.

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Dept of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.


In herpes simplex virus, the simplest path to resistance to the drug acyclovir is a mutation that knocks out the enzyme thymidine kinase. Such mutants are highly attenuated in mouse models of viral pathogenesis, but have been reported to be associated with severe disease in immunocompromised patients. This review discusses possible resolution of this paradox.

[Indexed for MEDLINE]

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