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Trends Microbiol. 1994 Dec;2(12):476-80.

Survival of the Q fever agent Coxiella burnetii in the phagolysosome.

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Dept of Biology, University of New Mexico, Albuquerque 87060.


The Q fever agent, Coxiella burnetii, thrives in the acidic environment of the phagolysosome of the host cell. How this obligate intracellular agent manages to survive within this hostile milieu is unknown; however, several of its enzymes may eliminate or prevent the formation of toxic oxygen metabolites by the host cell. Also implicated as virulence factors are its surface lipopolysaccharide and plasmids.

[Indexed for MEDLINE]

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