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Bone Marrow Transplant. 1994 Nov;14(5):845-8.

Successful treatment of chronic graft-versus-host disease with extracorporeal photopheresis.

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1
Department of Dermatology, University Medical Center Benjamin Franklin, Berlin, Germany.

Abstract

A 43-year-old woman who had undergone allogeneic bone marrow transplant for chronic myeloid leukemia developed chronic GVHD. Despite cyclosporine A and low-dose glucocorticoids and later concomittent PUVA-therapy, chronic GVHD with severe sclerodermatous manifestations including joint contracture and liver damage progressed. The Karnofsky performance score dropped to under 50%. Extracorporeal photopheresis (ECP) instead of PUVA-therapy was started. To our knowledge, we here report the first case of successful treatment of extensive chronic GVHD with ECP.

PMID:
7889018
[Indexed for MEDLINE]
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