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Immunol Today. 1995 Feb;16(2):90-8.

The basis of autoimmunity: Part I. Mechanisms of aberrant self-recognition.

Author information

1
Dept of Immunology, Scripps Research Institute, La Jolla, CA 92037.

Abstract

In this two-part series, Argyrios N. Theofilopoulos summarizes the current state of affairs in the field of autoimmunity. Part I integrates the collective mechanistic theories of autoimmune diseases. The most straightforward explanation to emerge with regard to organ-specific diseases is the concept that these are caused by inappropriate, yet conventional, immunological responses against self-antigens for which tolerance has never been established. A similar mechanism may be operative in systemic autoimmunity, but other abnormalities such as defects in the apoptosis machinery may also be invoked. Part II will address the genetic contributions predisposing to autoimmune syndromes.

PMID:
7888073
DOI:
10.1016/0167-5699(95)80095-6
[Indexed for MEDLINE]

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