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Immunol Today. 1995 Feb;16(2):61-7.

Post-thymectomy autoimmunity: abnormal T-cell homeostasis.

Author information

1
Cellular Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

Abstract

Thymectomy of 3-day-old mice induces organ-specific autoimmune disease, which is characterized by the presence of autoantibodies and T-cell infiltrates in the affected organs. Here, Adriana Bonomo and colleagues propose a new model for the pathogenesis of this syndrome, which integrates many of the homeostatic mechanisms of the immune system, including central and peripheral tolerance, T-cell maturation and exportation from the thymus, as well as lymphocyte recirculation and homing.

PMID:
7888068
DOI:
10.1016/0167-5699(95)80089-1
[Indexed for MEDLINE]

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