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Virology. 1995 Mar 10;207(2):460-6.

Serine/threonine protein phosphatase is required for tobacco mosaic virus-mediated programmed cell death.

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  • 1Department of Biology-LIF 136, University of South Florida, Tampa 33620-5150.

Abstract

A major gap in our understanding of host response to virus infection is how the molecular signals are passed within infected cells. Tobacco mosaic virus-mediated programmed cell death in genotype NN tobaccos was used to evaluate the hypothesis that these molecular signals are transduced via reversible-protein phosphorylation. Nicotiana tabacum L. (genotype NN) confers a hypersensitive response at the site of virus infection when incubated at a permissive temperature. Activation of serine/threonine protein phosphatase correlated with the temperature-dependent induction of the death program. The serine/threonine protein phosphatase inhibitor okadaic acid inhibited the onset and extent of the hypersensitive response in vivo. Biochemical analysis indicates that protein phosphatase type 1 is activated early in the death program. This is the first indication that serine/threonine protein phosphatase is required in an early event of the host response to virus infection.

PMID:
7886949
DOI:
10.1006/viro.1995.1105
[PubMed - indexed for MEDLINE]
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