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J Cell Sci Suppl. 1994;18:63-8.

Regulation of the cell cycle timing of Start in fission yeast by the rum1+ gene.

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Instituto de MicrobiologĂ­a BioquĂ­mica, CSIC/Universidad de Salamanca, Spain.


We have identified the rum1+ gene as a new regulator of the G1-phase of the fission yeast cell cycle. rum1+ determines the cell cycle timing of Start, by maintaining cells in a pre-Start state until they have attained a minimal critical mass. Cells lacking rum1+ are unable to arrest in pre-Start G1 in response to nitrogen starvation and are subsequently sterile. In addition, rum1+ prevents entry into mitosis from pre-Start G1, as shown by the fact that cdc10 mutants in the absence of rum1+ undergo lethal mitosis without entering S-phase.

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