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Br J Ophthalmol. 1995 Jan;79(1):50-3.

Herpetic eye attacks: variability of circannual rhythms.

Author information

1
Maurice and Gabriela Goldschleger Eye Institute, Sheba Medical Center, Tel-Hashomer, Israel.

Abstract

BACKGROUND:

The issue of seasonal variation of herpetic ocular infections is still controversial. This study was designed to examine whether this variation exists and can be defined as a significant circannual rhythm.

METHODS:

The patterns of recurrent attacks were monitored in 541 patients over a period of 15 years. Rhythm parameters were analysed according to age, sex, and clinical signs.

RESULTS:

The majority of herpetic eye attacks exhibited the highest peak in January (p < 0.04), except in the group of atopic children where the incidence of the disease peaked in September (p < 0.05). Among the various clinical forms, significant circannual periodicities were found only in the occurrence of epithelial herpetic keratitis (p < 0.03). The rhythms were detected among males (p < 0.03) but not among females. No direct correlation was demonstrated between the presence of the rhythms and the triggering effect of upper respiratory tract infections.

CONCLUSIONS:

Chronoepidemiological evaluation of individual reactivation patterns may be beneficial to certain patients and contribute to the optimisation of the treatment when prophylaxis is considered.

PMID:
7880794
PMCID:
PMC505020
DOI:
10.1136/bjo.79.1.50
[Indexed for MEDLINE]
Free PMC Article

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