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Curr Opin Cell Biol. 1994 Dec;6(6):872-6.

Cell cycle checkpoints.

Author information

1
University of California at San Francisco.

Abstract

Checkpoints help ensure that cell cycle events occur in the correct order. Studies on mammalian cells identified inhibitors of complexes of cyclins and cyclin-dependent kinases as components of cell cycle checkpoints and provide the first glimpse of the molecular pathways that prevent cells with damaged DNA from replicating their DNA. In embryos, the extent to which checkpoints arrest the cell cycle reflects the relative strength of inhibitory checkpoints and the machinery driving the cell cycle forward.

PMID:
7880536
DOI:
10.1016/0955-0674(94)90059-0
[Indexed for MEDLINE]

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