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Curr Opin Cell Biol. 1994 Dec;6(6):847-52.

Cdk inhibitors: on the threshold of checkpoints and development.

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Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030.


The regulation of cyclin-dependent kinases is at the heart of cell cycle control and, by inference, the control of cell proliferation. Recent advances in regulation of these kinases have uncovered a group of small proteins that bind to and inhibit them, thus preventing cell cycle progression. Linking these proteins to tumor suppressor functions has provided a much sought after connection between cancer and cell cycle control.

[Indexed for MEDLINE]

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