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Curr Opin Cell Biol. 1994 Dec;6(6):816-24.

Insights into erythroid differentiation obtained from studies on avian erythroblastosis virus.

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  • 1Institute of Molecular Pathology, Vienna, Austria.

Abstract

Analysis of the oncogenes v-erbB and v-erbA and their normal proto-oncogene counterparts has revealed several novel aspects of erythroid differentiation. A new erythroid progenitor capable of extended self-renewal has been described, tyrosine kinase receptors and steroid hormone receptors have been found to cooperate in controlling self-renewal, and dramatic alterations in the cell cycle have been found to accompany induction of terminal differentiation.

PMID:
7880528
[PubMed - indexed for MEDLINE]
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