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Curr Opin Cell Biol. 1994 Dec;6(6):809-15.

Differentiation and cell death: lessons from the immune system.

Author information

1
Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110.

Abstract

The immune system provides a unique vantage point from which to view the interrelationship between differentiation and cell death, as apoptosis is a prominent feature of B- and T-lymphocyte development. Two common themes emerge from recent experimental observations. First, survival signals are crucial during the differentiation process. The upregulation of Bcl-2 during positive selection suggests that this molecule serves as a survival signal to maintain lymphoid homeostasis. Second, if cell death is repressed, cellular differentiation can occur in the absence of inductive signals.

PMID:
7880527
DOI:
10.1016/0955-0674(94)90049-3
[Indexed for MEDLINE]

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