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Curr Opin Cell Biol. 1994 Dec;6(6):795-803.

Differentiation and self-renewal in the mouse gastrointestinal epithelium.

Author information

1
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110.

Abstract

The mouse gut epithelium represents a dynamic, geographically well organized, developmental system for examining self-renewal and differentiation. Reagents are now available for identifying the molecular mechanisms that regulate cell fate in the gut, the migration-associated differentiation programs of its component cell lineages, and its axial patterning. Considerable attention needs to be paid to two variables when studying gastrointestinal epithelial cell biology: space and time. This has necessitated the use of normal, chimeric, and transgenic animals as experimental models.

PMID:
7880525
DOI:
10.1016/0955-0674(94)90047-7
[Indexed for MEDLINE]

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