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Arthritis Rheum. 1995 Mar;38(3):381-3.

Occurrence of ankylosing spondylitis in a nationwide series of twins.

Author information

1
Rheumatism Foundation Hospital, Heinola, Finland.

Abstract

OBJECTIVE:

To obtain information on the rate of concordance for ankylosing spondylitis (AS) in a population-based series of twins.

METHODS:

AS cases were identified by record linkage of the population-based Finnish Twin Cohort and the nationwide registry for fully reimbursed medications. A clinical examination was performed to establish concordance for AS.

RESULTS:

There were 6 monozygotic (MZ) pairs and 20 dizygotic (DZ) pairs with at least 1 member affected by AS. Three MZ pairs and 3 DZ pairs were concordant for the disease. All affected subjects were HLA-B27 positive. The pairwise concordance rate was 50% in MZ twins and 20% in HLA-B27 positive DZ twins (95% confidence intervals 11.8-88.2% and 4.3%-48.1%, respectively).

CONCLUSION:

These results indicate that AS disease expression is largely, but not entirely, genetically based, with a gene or genes other than B27 probably playing a role.

PMID:
7880193
DOI:
10.1002/art.1780380313
[Indexed for MEDLINE]

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