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Trends Biochem Sci. 1995 Jan;20(1):33-7.

Neuronal cdc2-like kinase.

Author information

1
Department of Medical Biochemistry, University of Calgary, Health Sciences Center, Alberta, Canada.

Abstract

Neurofilament proteins and the neuron-specific microtubule-associated protein tau are phosphorylated in vivo at sites conforming to the phosphorylation consensus motif of the cell-cycle-control protein kinase, p34cdc2-cyclin. Abnormalities in the phosphorylation of these proteins are associated with neurodegenerative disorders, such as amylotrophic lateral sclerosis and Alzheimer's disease. A cdc2-like kinase composed of cyclin-dependent kinase 5 (cdk5) and a brain-specific regulatory subunit is proposed to be responsible for the cdc2-like phosphorylation of these neuronal proteins.

PMID:
7878742
[Indexed for MEDLINE]

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