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Physiol Behav. 1995 Jan;57(1):171-5.

Medial preoptic alpha-2 adrenoceptors in the regulation of sleep-wakefulness.

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1
Department of Physiology, All India Institute of Medical Sciences, New Delhi.

Abstract

Adrenergic alpha 2 agonist (clonidine) and its antagonist (yohimbine) were locally applied to the medial preoptic area (mPOA), to find out the role of alpha 2 receptors at this brain region in the regulation of sleep-wakefulness. Clonidine produced arousal, whereas yohimbine induced sleep in freely moving animals. Behavioural arousal produced by clonidine administration was accompanied by EEG synchronization. The alpha 2 receptor as the probable site of action of externally applied norepinephrine (NE), is discussed.

PMID:
7878113
[Indexed for MEDLINE]
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