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Med Hypotheses. 1994 Nov;43(5):339-42.

Arginine supplementation in the prevention and treatment of osteoporosis.

Author information

1
Department of Surgery, Free University Hospital, Amsterdam, The Netherlands.

Abstract

Oral administration of L-arginine in pharmacological doses induces growth hormone and insulin-like growth factor-I responses and stimulates nitric oxide synthesis. Growth hormone and insulin-like growth factor-I are important mediators of bone turnover and osteoblastic bone formation, while nitric oxide is a potent inhibitor of osteoclastic bone resorption. Because of this dual effect on physiological regulators of bone remodeling, L-arginine could potentially increase bone formation over bone resorption, and, consequently, increase bone mass. It is, therefore, hypothesized that oral supplementation of L-arginine may be a novel strategy in the prevention and treatment of osteoporosis. Studies of this simple, safe, and inexpensive therapy seem warranted.

PMID:
7877530
[Indexed for MEDLINE]

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