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Anticancer Res. 1994 Nov-Dec;14(6B):2425-8.

A multiwell assay for inhibitors of phosphatidylinositol-3-kinase and the identification of natural product inhibitors.

Author information

1
Arizona Cancer Center, University of Arizona, Tucson 85724.

Abstract

A convenient and reliable multisample assay for the screening of inhibitors of the growth factor signalling enzyme phosphatidylinositol-3-kinase (PtdIns-3-K) has been developed. Four natural product inhibitors of Ptdlns-3-K have been identified with IC50 values for hypericin 0.18 microM, emodin 3.3 microM, asperuloside 2.0 microM and uttronin A 1.1 microM.

PMID:
7872663
[Indexed for MEDLINE]

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