Synthesis of pyridylethenyl derivatives of 3H-pyrido[2,3-d]-pyrimidyn-4-on of expected depressive activity on central nervous system. Part I

F Herold; B Gutkowska; A Baranowski; M Kałucka; E Helbin

Synthesis of pyridylethenyl derivatives of 3H-pyrido[2,3-d]-pyrimidyn-4-on of expected depressive activity on central nervous system. Part I

Acta Pol Pharm. 1994;51(3):257-62.

Authors

F Herold¹, B Gutkowska, A Baranowski, M Kałucka, E Helbin

Affiliation

¹ Department of Drug Technology, School of Medicine, Warsaw, Poland.

PMID: 7872018

Abstract

Synthesis of 2-(pyridylethenyl) derivatives of 3H-pyrido[2,3-d]pyrimidin-4-on [Va-k] by condensation of selected 2-methyl-3H-pyrido[2,3-d]pyrimidin-4-ones [IVa-k] with nicotinic aldehyde is described. Compounds [Vh] and [Vi] showed weak analgetic activities.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Analgesics / chemical synthesis*
Analgesics / pharmacology
Analgesics / toxicity
Animals
Mice
Pyrimidines / chemical synthesis*
Pyrimidines / pharmacology
Pyrimidines / toxicity

Substances

Analgesics
Pyrimidines