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J Trauma. 1995 Feb;38(2):233-6.

A double-blinded prospective evaluation of recombinant human erythropoietin in acutely burned patients.

Author information

1
Augusta Regional Medical Center, Georgia.

Abstract

OBJECTIVE:

To evaluate the effects of recombinant human erythropoietin (r-HuEPO) in attempting to prevent anemia in acutely burned patients.

DESIGN:

Prospective double-blind randomized study of 40 patients.

METHODS:

Patients with burns from 25% to 65% total body surface were enrolled. r-HuEPO or a placebo was begun within 72 hours of admission. Cell blood count, reticulocyte counts, transfusion requirements, and blood loss were measured. Comparison was carried out by the unpaired t test.

MAIN RESULTS:

There was no statistically significant difference in hemoglobin, hematocrit, reticulocyte count, ferritin, serum iron, total iron blinding capacity, or transfusion requirements. In patients with burns from 25% to 35%, the reticulocyte counts were statistically significantly higher.

CONCLUSION:

In our work the administration of r-HuEPO in acutely burned patients did not prevent the development of postburn anemia or decrease transfusion requirements. Increased erythropoiesis in smaller burns (25% to 35%) was observed and may indicate a reason for further study.

[Indexed for MEDLINE]

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