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J Pediatr. 1995 Mar;126(3):380-6.

Long-term effects of L-thyroxine therapy for congenital hypothyroidism.

Author information

1
Department of Pediatrics (Endocrinology Division), University of Toronto, Canada.

Abstract

OBJECTIVE:

To study the effects of initial and concurrent dose levels of L-thyroxine on ability and behavior in children with congenital hypothyroidism.

METHODS:

An existing database, involving a large cohort of children with congenital hypothyroidism detected by neonatal screening, was analyzed retrospectively. There were 94 children: 89 were assessed at age 7 years for intelligence and selective cognitive abilities, and 87 at age 8 years for behavior, achievement, and selective abilities.

RESULTS:

Subjects were stratified by median split into low and high starting dose groups. The high-dose group performed better on indexes of intelligence, verbal ability, and memory but had more behavior problems reflecting increased anxiety, social withdrawal, and poorer concentration. The dose of L-thyroxine at age 8 years was negatively correlated with memory task performance.

CONCLUSION:

A higher starting dose of L-thyroxine is beneficial for subsequent intellectual outcome in children with congenital hypothyroidism but may be associated with internalizing behavior problems.

PMID:
7869196
DOI:
10.1016/s0022-3476(95)70452-3
[Indexed for MEDLINE]

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