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Trends Microbiol. 1994 Nov;2(11):431-7.

Animal models of Lyme disease: pathogenesis and immunoprophylaxis.

Author information

1
Tulane University Medical Center, Tulane Regional Primate Research Center, Covington, LA 70433.

Abstract

Valuable insights into the pathogenesis and immunoprophylaxis of Lyme disease are beginning to emerge from studies in animal models. This review highlights two animal models: the mouse, which has allowed us to investigate the role of both the immune response and spirochete phenotype in determining the outcome of the disease; and the Rhesus monkey, which manifests signs of nerve involvement, in addition to showing erythema migrans and arthritis.

PMID:
7866701
DOI:
10.1016/0966-842x(94)90800-1
[Indexed for MEDLINE]

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