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Clin Investig. 1994 Oct;72(10):772-4.

Localization of the bronchodilator effect induced by type A natriuretic peptide in asthmatic subjects.

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Abteilung Pneumologie, Medizinische Hochschule Hannover, Germany.


Type A natriuretic peptide (CDD/ANP-99-126) in its circulating form was analyzed with respect to the localization of its bronchodilating effects in asthmatic subjects in vivo. The intravenous infusion of 5.7, 11.4, and 17.1 pmol kg-1 min-1 CDD/ANP-99-126 caused a significant bronchodilation of both central and peripheral airways. While the localization of the bronchodilating effects was similar to beta 2-agonists, an improvement in lung function parameters comparable to these substances was not observed. But other members of the natriuretic peptide family may reveal a stronger bronchodilating potency.

[Indexed for MEDLINE]

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