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J Neural Transm Gen Sect. 1994;95(2):157-62.

Organization of the human serotonin transporter gene.

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Department of Psychiatry, University of W├╝rzburg, Federal Republic of Germany.


The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized. The human 5-HTT gene is composed of 14 exons spanning approximately 31 kb. The sequence of all exons including adjacent intronic sequences and a tandem repeat DNA polymorphism (VNTR) has been determined and deposited in the EMBL/GenBank data base with the accession numbers X76753 to X76762. The characterization of 5-HTT gene will aid to advance molecular pharmacologic studies of 5-HT uptake regulation and facilitate investigations of its role in psychiatric disorders.

[Indexed for MEDLINE]

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