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Arch Ophthalmol. 1995 Feb;113(2):216-21.

Hypertension, perfusion pressure, and primary open-angle glaucoma. A population-based assessment.

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1
Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Md.

Abstract

OBJECTIVE:

To evaluate the association of vascular factors with primary open-angle glaucoma (POAG).

DESIGN:

A population-based prevalence survey of ocular disease among black and white residents.

SETTING:

Communities of east Baltimore, Md.

PARTICIPANTS:

A stratified cluster sample of 5308 residents 40 years of age or older.

MAIN OUTCOME MEASURES:

Primary open-angle glaucoma as defined by demonstrable glaucomatous optic nerve damage based on visual fields and/or optic disc findings. Intraocular pressure level was not a criterion for diagnosis.

RESULTS:

Systolic and diastolic blood pressure showed modest, positive association with POAG. The effect of blood pressure on POAG was modified by age, with a stronger association among older subjects. Lower perfusion pressure (blood pressure-intraocular pressure) was strongly associated with an increased prevalence of POAG, with a sixfold excess for those in the lowest category of perfusion pressure.

CONCLUSION:

These results suggest that POAG is associated with an alteration in factors related to ocular blood flow and a breakdown of autoregulation.

PMID:
7864755
[Indexed for MEDLINE]
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