Format

Send to

Choose Destination
J Cereb Blood Flow Metab. 1995 Mar;15(2):242-7.

In vivo detection of superoxide anion production by the brain using a cytochrome c electrode.

Author information

1
Department of Neurology, University of Texas Medical Branch at Galveston 77555-0539.

Abstract

A cytochrome c-coated platinized carbon electrode was utilized to detect superoxide generated by the brain during hypoxia/hypercarbia, focal ischemia, and reperfusion and following fluid percussion brain injury with and without hemorrhagic hypotension and reperfusion in the rat. All three of these forms of brain injury were associated with an increase in the superoxide signal. The cytochrome c electrode proved to be sensitive and responsive enough for minute-by-minute measurement of superoxide generation by brain tissue.

PMID:
7860658
DOI:
10.1038/jcbfm.1995.30
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center