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Eur J Pediatr. 1994 Dec;153(12):903-5.

Pulmonary effects of closure of patent ductus arteriosus in premature infants with severe respiratory distress syndrome.

Author information

1
Department of Paediatrics, Rikshospitalet, Oslo, Norway.

Abstract

The pulmonary effects of closure of a patent ductus arteriosus (PDA) were investigated in 11 premature infants with severe respiratory distress syndrome. Successful closure of a PDA did not improve the short-term severity of pulmonary disease (24 and 48 h after treatment) as judged by the arterial/alveolar oxygen tension ratio or the amount of ventilatory support. Also, pulmonary mechanics measured 24 h before, 24 and 48 h after treatment, were not statistically different.

CONCLUSION:

Infants with severe respiratory disease requiring high ventilation pressure and high oxygen concentration, where structural changes in the lungs are already established, will rarely show short-term improvement in pulmonary disease as a result of closure of a PDA. The overall clinical condition may, however, improve as a result of reduced cardiovascular strain. Earlier treatment of a PDA could reduce the ventilation period and the possible risk of developing chronic lung disease.

PMID:
7859794
DOI:
10.1007/bf01954743
[Indexed for MEDLINE]

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