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Trends Biochem Sci. 1994 Nov;19(11):485-90.

Histidine and aspartate phosphorylation: two-component systems and the limits of homology.

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Division of Biology, California Institute of Technology, Pasadena 91125.


Autophosphorylating histidine kinase and response-regulator domains constitute the building blocks of two-component signaling systems. These systems use a unique phosphotransfer chemistry to regulate many aspects of bacterial physiology. Homologous systems are now being found in eukaryotes. Despite their common mechanism of phosphotransfer, the two-component systems display an extensive diversity in the arrangement of their domains, and flexibility in their roles in different signal transduction circuits.

[Indexed for MEDLINE]

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