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Trends Biochem Sci. 1994 Nov;19(11):474-80.

The ins and outs of Raf kinases.

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Institute of Medical Radiobiology and Cell Biology, University of W├╝rzburg, Germany.


Raf kinases are signal-integrating enzymes that have the ability to switch tyrosine kinase signalling to serine/threonine phosphorylation and connect growth factor receptors with transcription factors. The connection involves a cascade of protein kinases that is essential for cellular proliferation and differentiation of species ranging from worms to humans. This cascade also mediates transformation by most oncogenes.

[Indexed for MEDLINE]

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