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Trends Biochem Sci. 1994 Nov;19(11):464-9.

Regulation of protein tyrosine kinases in platelets.

Author information

1
ARIAD Pharmaceuticals Inc., Cambridge, MA 02139.

Abstract

Platelet activation is accompanied by a dramatic increase in tyrosine phosphorylation of many cellular proteins. Phosphorylation of these proteins occurs in successive waves during the activation process, suggesting that several distinct mechanisms, occurring in a temporal order, regulate protein tyrosine kinases and/or phosphatases in activated platelets. Several tyrosine kinases, including Src family kinases, Syk and FAK, have been implicated in these phosphorylation events. These kinases are regulated by distinct receptor-mediated events involving activation of their catalytic activity and alterations in their cellular localization.

PMID:
7855888
DOI:
10.1016/0968-0004(94)90131-7
[Indexed for MEDLINE]

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