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J Urol. 1995 Mar;153(3 Pt 2):1066-9.

Primary yolk sac tumor of the prostate in a patient with Klinefelter's syndrome.

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  • 1Department of Pathology, University of California, San Diego.


Primary yolk sac (endodermal sinus) tumor of the prostate is extremely rare with only 2 cases reported in the literature. We describe a case of primary yolk sac tumor of the prostate in a man with Klinefelter's syndrome. Treatment included 4 courses of combination chemotherapy followed by retroperitoneal lymph node dissection, cystoprostatectomy and ileal conduit urinary diversion. We review the association of Klinefelter's syndrome with extragonadal germ cell tumor along with the management of this rare disease.

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