Protein kinase C inhibitors: novel spirosesquiterpene aldehydes from a marine sponge Aka (= Siphonodictyon) coralliphagum

J A Chan; A J Freyer; B K Carté; M E Hemling; G A Hofmann; M R Mattern; M A Mentzer; J W Westley

doi:10.1021/np50113a011

Protein kinase C inhibitors: novel spirosesquiterpene aldehydes from a marine sponge Aka (= Siphonodictyon) coralliphagum

J Nat Prod. 1994 Nov;57(11):1543-8. doi: 10.1021/np50113a011.

Authors

J A Chan¹, A J Freyer, B K Carté, M E Hemling, G A Hofmann, M R Mattern, M A Mentzer, J W Westley

Affiliation

¹ Research and Development, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939.

PMID: 7853003
DOI: 10.1021/np50113a011

Abstract

Two novel spirosesquiterpene aldehydes, corallidictyals A [1] and B [2], were isolated as a mixture from the marine sponge Aka (= Siphonodictyon) coralliphagum, and their structures were determined by detailed spectroscopic methods. These compounds were identified in a screen for inhibitors of protein kinase C.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Division / drug effects*
Chlorocebus aethiops
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Models, Molecular
Molecular Conformation
Molecular Structure
Porifera*
Protein Kinase C / antagonists & inhibitors*
Recombinant Proteins / antagonists & inhibitors
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology
Spiro Compounds / isolation & purification*
Spiro Compounds / pharmacology
Structure-Activity Relationship
Vero Cells

Substances

Recombinant Proteins
Sesquiterpenes
Spiro Compounds
corallidictyal A
Protein Kinase C