Periodontal manifestation of hypophosphatasia. A family case report

J Clin Periodontol. 1994 Nov;21(10):710-6. doi: 10.1111/j.1600-051x.1994.tb00791.x.

Abstract

Hypophosphatasia is a rare inherited disease, the 1st clinical sign of which is often a premature loss of deciduous teeth. We describe clinical, histological and SEM findings of 2 cases of hypophosphatasia from a single family and discuss the pathological mechanisms with reference to the literature.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Alkaline Phosphatase / blood
  • Alveolar Bone Loss / etiology
  • Child, Preschool
  • Dental Cementum / pathology
  • Dental Pulp / pathology
  • Female
  • Humans
  • Hypophosphatasia / genetics*
  • Hypophosphatasia / pathology
  • Infant
  • Male
  • Periodontal Diseases / etiology*
  • Periodontal Ligament / pathology
  • Root Resorption / etiology
  • Root Resorption / pathology
  • Tooth Exfoliation / etiology*
  • Tooth Exfoliation / pathology
  • Tooth, Deciduous* / pathology

Substances

  • Alkaline Phosphatase