Abstract
Hypophosphatasia is a rare inherited disease, the 1st clinical sign of which is often a premature loss of deciduous teeth. We describe clinical, histological and SEM findings of 2 cases of hypophosphatasia from a single family and discuss the pathological mechanisms with reference to the literature.
MeSH terms
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Alkaline Phosphatase / blood
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Alveolar Bone Loss / etiology
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Child, Preschool
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Dental Cementum / pathology
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Dental Pulp / pathology
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Female
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Humans
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Hypophosphatasia / genetics*
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Hypophosphatasia / pathology
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Infant
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Male
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Periodontal Diseases / etiology*
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Periodontal Ligament / pathology
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Root Resorption / etiology
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Root Resorption / pathology
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Tooth Exfoliation / etiology*
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Tooth Exfoliation / pathology
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Tooth, Deciduous* / pathology