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Circ Shock. 1994 Jul;43(3):137-53.

Human responses to bacterial endotoxin.

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Department of Microbiology and Immunology, West Virginia University Health Sciences Center, Morgantown 26506-9177.


The literature concerning human responses to bacterial endotoxin, in particular to the purified lipopolysaccharide derivative, has been critically reviewed and summarized. Papers selected for review are those that reported studies of human subjects in a normal state of health administered defined doses of either intravenous or aerosol inhaled material. Emphasis was placed on cardiovascular, pulmonary, metabolic, and inflammatory parameters. The information detailed here can be applied to understanding the pathophysiology of human consequences to spontaneous, clinical diseases induced by this highly inflammatory and ubiquitous substance.

[Indexed for MEDLINE]

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